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UniProt functional annotation for P29274 | ||
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| UniProt code: P29274. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). {ECO:0000250|UniProtKB:P11617}. |
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| Subunit: | |
Interacts (via cytoplasmic C-terminal domain) with USP4; the interaction is direct (PubMed:16339847). May interact with DRD4 (PubMed:18832607). Interacts with NECAB2 (PubMed:17689978). Interacts (via cytoplasmic C-terminal domain) with GAS2L2; interaction enhances receptor-mediated adenylyl cyclase activity (By similarity). {ECO:0000250|UniProtKB:P30543, ECO:0000269|PubMed:16339847, ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:18832607}. |
| Subcellular location: | |
Cell membrane {ECO:0000250|UniProtKB:P30543}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30543}. Note=Colocalizes with GAS2L2 at neuronal processes. {ECO:0000250|UniProtKB:P30543}. |
| Domain: | |
The cytoplasmic C-terminal domain is necessary for targeting the non-ubiquitinated form of this protein to the cell surface. |
| Ptm: | |
Ubiquitinated. Deubiquitinated by USP4; leading to stabilization and expression at the cell surface. {ECO:0000269|PubMed:16339847}. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
| Sequence caution: | |
Sequence=AAA58356.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.