UniProt functional annotation for P0DTC9



	UniProt functional annotation for P0DTC9

UniProt code: P0DTC9.

Organism: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2).

Taxonomy: Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus.

Function: Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (By similarity). May modulate transforming growth factor-beta signaling by binding host smad3 (By similarity). {ECO:0000250|UniProtKB:P59595, ECO:0000255|HAMAP-Rule:MF_04096}.

Subunit: Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with protein E. May bind to host HNRNPA1. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection (By similarity). May interact with host SMAD3 (By similarity). {ECO:0000250|UniProtKB:P59595, ECO:0000255|HAMAP-Rule:MF_04096}.

Subcellular location: Virion {ECO:0000255|HAMAP-Rule:MF_04096}. Host cytoplasm {ECO:0000269|PubMed:33060197}. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER- derived membranes where it participates in viral RNA synthesis and virus budding. {ECO:0000255|HAMAP-Rule:MF_04096}.

Ptm: ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection. {ECO:0000255|HAMAP-Rule:MF_04096}.

Ptm: Phosphorylated on serine and threonine residues. {ECO:0000255|HAMAP-Rule:MF_04096}.

Polymorphism: Variant B.1.1.7 is also called Variant Of Concern (VOC) 202012/01, Variant Under Investigation (VUI) 202012/01, or 20B/501Y.V1. {ECO:0000305|PubMed:33413740}.

Similarity: Belongs to the betacoronavirus nucleocapsid protein family. {ECO:0000255|HAMAP-Rule:MF_04096}.

Annotations taken from UniProtKB at the EBI.


Organism:		Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2).
Taxonomy:		Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus.



Function:		Packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication (By similarity). May modulate transforming growth factor-beta signaling by binding host smad3 (By similarity). {ECO:0000250\|UniProtKB:P59595, ECO:0000255\|HAMAP-Rule:MF_04096}.


Subunit:		Homooligomer. Both monomeric and oligomeric forms interact with RNA. Interacts with protein M. Interacts with protein E. May bind to host HNRNPA1. Interacts with NSP3; this interaction serves to tether the genome to the newly translated replicase-transcriptase complex at a very early stage of infection (By similarity). May interact with host SMAD3 (By similarity). {ECO:0000250\|UniProtKB:P59595, ECO:0000255\|HAMAP-Rule:MF_04096}.
Subcellular location:		Virion {ECO:0000255\|HAMAP-Rule:MF_04096}. Host cytoplasm {ECO:0000269\|PubMed:33060197}. Note=Located inside the virion, complexed with the viral RNA. Probably associates with ER- derived membranes where it participates in viral RNA synthesis and virus budding. {ECO:0000255\|HAMAP-Rule:MF_04096}.
Ptm:		ADP-ribosylated. The ADP-ribosylation is retained in the virion during infection. {ECO:0000255\|HAMAP-Rule:MF_04096}.
Ptm:		Phosphorylated on serine and threonine residues. {ECO:0000255\|HAMAP-Rule:MF_04096}.
Polymorphism:		Variant B.1.1.7 is also called Variant Of Concern (VOC) 202012/01, Variant Under Investigation (VUI) 202012/01, or 20B/501Y.V1. {ECO:0000305\|PubMed:33413740}.
Similarity:		Belongs to the betacoronavirus nucleocapsid protein family. {ECO:0000255\|HAMAP-Rule:MF_04096}.