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UniProt functional annotation for P62871 | ||
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| UniProt code: P62871. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
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| Subunit: | |
G proteins are composed of 3 units, alpha, beta and gamma (PubMed:8521505). The heterodimer formed by GNB1 and GNG2 interacts with ARHGEF5 (By similarity). The heterodimer formed by GNB1 and GNG2 interacts with GRK2 (PubMed:12764189). Interacts with ARHGEF18 and RASD2 (By similarity). {ECO:0000250|UniProtKB:P62873, ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:8521505}. |
| Ptm: | |
Phosphorylation at His-266 by NDKB contributes to G protein activation by increasing the high energetic phosphate transfer onto GDP. {ECO:0000269|PubMed:12486123}. |
| Similarity: | |
Belongs to the WD repeat G protein beta family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.