PDBsum entry 9bkk

Membrane protein

PDB id: 9bkk

Contents

Protein chains

203 a.a.

339 a.a.

57 a.a.

283 a.a.

Ligands

ASP-TYS-MET-GLY-TRP-MET-ASP-PHE-NH2

PDB id:

9bkk

Name:

Membrane protein

Title:

Cholecystokinin 1 receptor (cck1r) sterol 7m mutant, gq chimera (mgsqi) complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein,extra large alphas protein,xlalphas. Engineered: yes. Other_details: guanine nucleotide-binding protein g(i) subunit alpha- 1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short,with certain residues mutated to match guanine nucleotide-

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Synthetic: yes.

Authors:

K.G.Harikumar,P.Zhao,B.P.Cary,X.Xu,A.J.Desai,J.I.Mobbs,C.Toufaily, S.G.B.Furness,A.Christopoulos,M.J.Belousoff,D.Wootten,P.M.Sexton, L.J.Miller

Key ref:

K.G.Harikumar et al. Cholesterol-Dependent dynamic changes in the conforma the type 1 cholecystokinin receptor affect ligand bin and g protein coupling. To be published, . PubMed id: 39083706

Date:

29-Apr-24 Release date: 22-May-24

Protein chain

Q5JWF2  (GNAS1_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas from Homo sapiens

Seq: 1037 a.a.

Struc: 203 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P32238  (CCKAR_HUMAN) -  Cholecystokinin receptor type A from Homo sapiens

Seq: 428 a.a.

Struc: 283 a.a.*

* PDB and UniProt seqs differ at 62 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????