PDBsum entry 9bhl

Signaling protein

PDB id: 9bhl

Contents

Protein chains

240 a.a.

300 a.a.

128 a.a.

301 a.a.

PDB id:

9bhl

Name:

Signaling protein

Title:

Human proton sensing receptor gpr65 in complex with minigs

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Other_details: minigs. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gnb1. Lama glama. Organism_taxid: 9844.

Authors:

M.K.Howard,N.Hoppe,X.P.Huang,C.B.Macdonald,E.Mehrotra,P.Rockefeller Grimes,A.M.Zahm,D.D.Trinidad,J.English,W.Coyote-Maestas,A.Manglik

Key ref:

M.K.Howard et al. Molecular basis of proton sensing by g protein-Couple receptors.. Cell, . PubMed id: 39753132

Date:

21-Apr-24 Release date: 22-Jan-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 240 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 300 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

Q8IYL9  (PSYR_HUMAN) -  Psychosine receptor from Homo sapiens

Seq: 337 a.a.

Struc: 301 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????