PDBsum entry 9b65

Signaling protein

PDB id: 9b65

Contents

Protein chains

218 a.a.

338 a.a.

57 a.a.

266 a.a.

232 a.a.

Ligands

KCA

PDB id:

9b65

Name:

Signaling protein

Title:

Biased agonist bound cb1-gi structure

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Gene: cnr1, cnr.

Authors:

V.A.Rangari,E.S.O'Brien,B.K.Kobilka,K.Krishna Kumar,S.Majumdar

Key ref:

V.A.Rangari et al. A cryptic pocket in cb1 drives peripheral and functio selectivity.. Nature, . PubMed id: 40044849

Date:

23-Mar-24 Release date: 05-Mar-25

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 218 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P21554  (CNR1_HUMAN) -  Cannabinoid receptor 1 from Homo sapiens

Seq: 472 a.a.

Struc: 266 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????