PDBsum entry 9o38

Hydrolase/immune system

PDB id: 9o38

Contents

Protein chains

238 a.a.

339 a.a.

53 a.a.

128 a.a.

257 a.a.

243 a.a.

PDB id:

9o38

Name:

Hydrolase/immune system

Title:

Transmembrane domains of the human sweet receptor (tas1r2 + tas1r3) from class 3 particles (rigidly fitted from pdb:9nox and 9nor)

Structure:

Taste receptor type 1 member 3,guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: b, f. Synonym: sweet taste receptor t1r3,adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: tas1r3, t1r3, tr3, gnas, gnas1, gsp. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

Z.Juen,Z.Lu,R.Yu,A.N.Chang,B.Wang,A.W.P.Fitzpatrick,C.S.Zuker

Key ref:

Z.Juen et al. The structure of human sweetness. Cell(cambridge,Mass ), . PubMed id: 40339580

Date:

06-Apr-25 Release date: 14-May-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 238 a.a.*

Protein chain

Q7RTX0  (TS1R3_HUMAN) -  Taste receptor type 1 member 3 from Homo sapiens

Seq: 852 a.a.

Struc: 238 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

Q8TE23  (TS1R2_HUMAN) -  Taste receptor type 1 member 2 from Homo sapiens

Seq: 839 a.a.

Struc: 257 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 243 a.a.*

Protein chain

Q7RTX0  (TS1R3_HUMAN) -  Taste receptor type 1 member 3 from Homo sapiens

Seq: 852 a.a.

Struc: 243 a.a.*

* PDB and UniProt seqs differ at 378 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains B, F: E.C.3.6.5.- - ?????