PDBsum entry 9md1

Signaling protein

PDB id: 9md1

Contents

Protein chains

120 a.a.

321 a.a.

280 a.a.

43 a.a.

Ligands

YLX ×2

CLR ×8

J40 ×2

PDB id:

9md1

Name:

Signaling protein

Title:

Buspirone-bound serotonin 1a (5-ht1a) receptor-gz protein complex

Structure:

Guanine nucleotide-binding protein g(z) subunit alpha. Chain: a. Synonym: g(x) alpha chain,gz-alpha. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnaz. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Escherichia coli, homo sapiens. Organism_taxid: 562, 9606.

Authors:

A.L.Warren,G.Zilberg,D.Wacker

Key ref:

A.L.Warren et al. (2025). Structural determinants of g protein subtype selectiv the serotonin receptor 5-Ht1a.. Sci adv, 11, u9851. PubMed id: 40749070 DOI: 10.1126/SCIADV.ADU9851

Date:

05-Dec-24 Release date: 13-Aug-25

Protein chain

P19086  (GNAZ_HUMAN) -  Guanine nucleotide-binding protein G(z) subunit alpha from Homo sapiens

Seq: 355 a.a.

Struc: 120 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 321 a.a.

Protein chains

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 280 a.a.*

Protein chains

P08908  (5HT1A_HUMAN) -  5-hydroxytryptamine receptor 1A from Homo sapiens

Seq: 422 a.a.

Struc: 280 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 43 a.a.

* PDB and UniProt seqs differ at 150 residue positions (black crosses)