PDBsum entry 9m1h

Membrane protein

PDB id: 9m1h

Contents

Protein chains

286 a.a.

232 a.a.

338 a.a.

54 a.a.

Ligands

P2E

Waters ×1

PDB id:

9m1h

Name:

Membrane protein

Title:

Cryo-em structure of pge2-ep1-gq complex

Structure:

Prostaglandin e2 receptor ep1 subtype. Chain: a. Synonym: pge receptor ep1 subtype,pge2 receptor ep1 subtype, prostanoid ep1 receptor. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(q) subunit alpha. Chain: b.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptger1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnai1, gnas, gnas1, gsp, gnaq, gaq. Gene: gnb1. Gene: gng2.

Authors:

X.Meng,Y.Xu,H.E.Xu

Key ref:

X.Meng et al. Structural insights into the activation of human prostaglandin e2 receptor ep1 subtype by prostaglandi. To be published, . PubMed id: 40366695

Date:

26-Feb-25 Release date: 30-Apr-25

Protein chain

P34995  (PE2R1_HUMAN) -  Prostaglandin E2 receptor EP1 subtype from Homo sapiens

Seq: 402 a.a.

Struc: 286 a.a.

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 232 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 232 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 232 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 54 a.a.

* PDB and UniProt seqs differ at 344 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????