PDBsum entry 9lgm

Signaling protein/immune system

PDB id: 9lgm

Contents

Protein chains

239 a.a.

338 a.a.

56 a.a.

127 a.a.

289 a.a.

PDB id:

9lgm

Name:

Signaling protein/immune system

Title:

Cryo-em structure of gpr4 complexed with gs in ph8.0

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

X.L.Yue,L.J.Wu,T.Hua,Z.J.Liu

Key ref:

X.Yue et al. Structural basis of stepwise proton sensing-Mediated activation.. Cell res, . PubMed id: 40211064

Date:

10-Jan-25 Release date: 23-Apr-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 239 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

P46093  (GPR4_HUMAN) -  G-prodeshotein coupled receptor 4 from Homo sapiens

Seq: 362 a.a.

Struc: 289 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????