PDBsum entry 9l3y

Membrane protein

PDB id: 9l3y

Contents

Protein chains

298 a.a.

103 a.a.

211 a.a.

330 a.a.

51 a.a.

PDB id:

9l3y

Name:

Membrane protein

Title:

Cryo-em structure of the g-protein coupled receptor 1 (gpr1) in complex with chemerin and gi1

Structure:

Chemerin-like receptor 2. Chain: r. Synonym: g-protein coupled receptor 1 (gpr1),chemerin chemokine-like receptor 2,chemokine-like receptor 2. Engineered: yes. Retinoic acid receptor responder protein 2. Chain: l. Synonym: chemerin,rar-responsive protein tig2,tazarotene-induced gene 2 protein.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cmklr2, gpr1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: rarres2, tig2. Gene: gnai1. Gene: gnb1.

Authors:

Y.Zhu,M.He,B.Wu,Q.Zhao

Key ref:

X.Lin et al. Structural insights into the distinct ligand recognit signaling of the chemerin receptors cmklr1 and gpr1.. Protein cell, . PubMed id: 39752296

Date:

19-Dec-24 Release date: 12-Mar-25

Protein chain

P46091  (GPR1_HUMAN) -  Chemerin-like receptor 2 from Homo sapiens

Seq: 355 a.a.

Struc: 298 a.a.

Protein chain

Q99969  (RARR2_HUMAN) -  Retinoic acid receptor responder protein 2 from Homo sapiens

Seq: 163 a.a.

Struc: 103 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 211 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 330 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????