PDBsum entry 9kfk

Structural protein/immune system

PDB id: 9kfk

Contents

Protein chains

55 a.a.

219 a.a.

284 a.a.

230 a.a.

338 a.a.

19 a.a.

24 a.a.

PDB id:

9kfk

Name:

Structural protein/immune system

Title:

Cryo-em structure of the relaxin-3-bound human relaxin family peptide receptor 4 (rxfp4)-gi complex

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: g. Synonym: g gamma-i. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-2. Chain: i. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Bos taurus. Domestic cattle. Organism_taxid: 9913. Gene: gng2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Authors:

Y.Chen,Q.T.Zhou,S.Y.Yan,J.H.Yan,D.H.Yang,J.Chen,M.W.Wang

Key ref:

Y.Chen et al. (2025). Molecular mechanism underlying non-Discriminatory recognition of relaxin-3 by rxfp3 and rxfp4.. Commun biol, 8, 794. PubMed id: 40410443 DOI: 10.1038/S42003-025-08220-7

Date:

06-Nov-24 Release date: 13-Aug-25

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 219 a.a.*

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 284 a.a.*

Protein chain

Q8TDU9  (RL3R2_HUMAN) -  Relaxin-3 receptor 2 from Homo sapiens

Seq: 374 a.a.

Struc: 284 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

Q8WXF3  (REL3_HUMAN) -  Relaxin-3 from Homo sapiens

Seq: 142 a.a.

Struc: 19 a.a.

Protein chain

Q8WXF3  (REL3_HUMAN) -  Relaxin-3 from Homo sapiens

Seq: 142 a.a.

Struc: 24 a.a.

* PDB and UniProt seqs differ at 160 residue positions (black crosses)