PDBsum entry 9k6l

Signaling protein/immune system

PDB id: 9k6l

Contents

Protein chains

226 a.a.

341 a.a.

57 a.a.

232 a.a.

271 a.a.

Ligands

SA0

PDB id:

9k6l

Name:

Signaling protein/immune system

Title:

Cryo-em structure of gpcr16-gi2 complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-2. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai2, gnai2b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Streptococcus pneumoniae, homo sapiens,

Authors:

X.Wang,C.Zhou,L.J.Wu,T.Hua,Z.J.Liu

Key ref:

X.Wang et al. Cryo-Em structure of gpcr16-Gi2 complex. To be published, . PubMed id: 40261795

Date:

22-Oct-24 Release date: 02-Apr-25

Protein chain

P04899  (GNAI2_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-2 from Homo sapiens

Seq: 355 a.a.

Struc: 226 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 341 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

Q9NYV7  (T2R16_HUMAN) -  Taste receptor type 2 member 16 from Homo sapiens

Seq: 291 a.a.

Struc: 271 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain R: E.C.3.2.1.18 - exo-alpha-sialidase.
• Reaction: Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.