PDBsum entry 9k3k

Membrane protein

PDB id: 9k3k

Contents

Protein chains

270 a.a.

234 a.a.

340 a.a.

55 a.a.

127 a.a.

230 a.a.

PDB id:

9k3k

Name:

Membrane protein

Title:

Cryo-em structure of the unliganded human melanocortin receptor 4 (mc4r)-gs complex

Structure:

Melanocortin receptor 4,melanocortin receptor 4, melanocortin receptor 4,lgbit subunit. Chain: r. Synonym: mc4-r. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein,adenylate

Source:

Homo sapiens, synthetic construct. Human. Organism_taxid: 9606, 32630. Gene: mc4r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Organism_taxid: 9606. Gene: gnai1, gnas, gnas1, gsp.

Authors:

W.B.Feng,Q.T.Zhou,C.Zheng,D.H.Yang,M.W.Wang

Key ref:

W.Feng et al. (2025). Structural basis for the constitutive activity of the melanocortin receptor family.. Structure, 33, 1074. PubMed id: 40157361 DOI: 10.1016/J.STR.2025.03.004

Date:

19-Oct-24 Release date: 06-Aug-25

Protein chain

P32245  (MC4R_HUMAN) -  Melanocortin receptor 4 from Homo sapiens

Seq: 332 a.a.

Struc: 270 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 234 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 234 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 340 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 127 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.

* PDB and UniProt seqs differ at 202 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????