PDBsum entry 9k25

Membrane protein

PDB id: 9k25

Contents

Protein chains

212 a.a.

323 a.a.

37 a.a.

278 a.a.

126 a.a.

PDB id:

9k25

Name:

Membrane protein

Title:

Cryo-em structure of apo-p2y purinoceptor 2-minigq-nb35 complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gnb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Authors:

B.Lan,S.Zhang,X.Liu,B.Lin

Key ref:

B.Lan et al. (2025). Structural insight into the self-Activation and g-Pro coupling of p2y2 receptor.. Cell discov, 11, 47. PubMed id: 40360475

Date:

17-Oct-24 Release date: 11-Jun-25

Protein chain

No UniProt id for this chain

Struc: 212 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 323 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 37 a.a.

Protein chain

P41231  (P2RY2_HUMAN) -  P2Y purinoceptor 2 from Homo sapiens

Seq: 377 a.a.

Struc: 278 a.a.*

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????