PDBsum entry 9k20

Membrane protein

PDB id: 9k20

Contents

Protein chains

288 a.a.

213 a.a.

331 a.a.

50 a.a.

229 a.a.

Ligands

ATP

PDB id:

9k20

Name:

Membrane protein

Title:

Cryo-em structure of atp-bound p2y purinoceptor 2-minigo-scfv16 complex

Structure:

P2y purinoceptor 2. Chain: a. Synonym: p2y2,atp receptor,p2u purinoceptor 1,p2u1,p2u receptor 1, purinergic receptor. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(o) subunit alpha. Chain: b. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: p2ry2, p2ru1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gnao1. Gene: gnb1. Expressed in: trichoplusia ni.

Authors:

B.Lan,S.Zhang,X.Liu,B.Lin

Key ref:

B.Lan et al. (2025). Structural insight into the self-Activation and g-Pro coupling of p2y2 receptor.. Cell discov, 11, 47. PubMed id: 40360475

Date:

16-Oct-24 Release date: 11-Jun-25

Protein chain

P41231  (P2RY2_HUMAN) -  P2Y purinoceptor 2 from Homo sapiens

Seq: 377 a.a.

Struc: 288 a.a.*

Protein chain

P09471  (GNAO_HUMAN) -  Guanine nucleotide-binding protein G(o) subunit alpha from Homo sapiens

Seq: 354 a.a.

Struc: 213 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 331 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 50 a.a.

Protein chain

No UniProt id for this chain

Struc: 229 a.a.

* PDB and UniProt seqs differ at 57 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain B: E.C.3.6.5.- - ?????