PDBsum entry 9j8z

Membrane protein

PDB id: 9j8z

Contents

Protein chains

337 a.a.

216 a.a.

56 a.a.

233 a.a.

279 a.a.

PDB id:

9j8z

Name:

Membrane protein

Title:

Cryo-em structure of human hcar1-gi complex without ligand (apo state)

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: c. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnai1. Gene: gng2. Gene: hcar1, gpr104, gpr81, hca1, fksg80.

Authors:

P.Xin,Y.Fang

Key ref:

P.Xin and y.fang Cryo-Em structure of human hcar1-Gi complex without l (apo state). To be published, . PubMed id: 40233099

Date:

21-Aug-24 Release date: 02-Apr-25

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 216 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

Q9BXC0  (HCAR1_HUMAN) -  Hydroxycarboxylic acid receptor 1 from Homo sapiens

Seq: 346 a.a.

Struc: 279 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????