PDBsum entry 9j1p

Membrane protein

PDB id: 9j1p

Contents

Protein chains

235 a.a.

338 a.a.

51 a.a.

124 a.a.

49 a.a.

389 a.a.

PDB id:

9j1p

Name:

Membrane protein

Title:

Cryo-em structure of the g1:ox-bound human glp-1r-gs complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short, guanine nucleotide-binding protein g(s) subunit alpha isoforms xlas. Chain: a. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1, gnas. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Rattus norvegicus. Norway rat. Organism_taxid: 10116.

Authors:

S.Fan,J.Li,J.Zhuang,Q.Zhou,Y.Mai,B.Lin,M.-W.Wang,C.Wu

Key ref:

S.Fan et al. (2025). Disulfide-Directed multicyclic peptides with n-Termin extendable alpha-Helices for recognition and activati protein-Coupled receptors.. J am chem soc, 147, 4821. PubMed id: 39688263

Date:

05-Aug-24 Release date: 26-Feb-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 235 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 235 a.a.*

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

No UniProt id for this chain

Struc: 124 a.a.

Protein chain

No UniProt id for this chain

Struc: 49 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 389 a.a.

* PDB and UniProt seqs differ at 215 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????