PDBsum entry 9ivg

Membrane protein

PDB id: 9ivg

Contents

Protein chains

21 a.a.

384 a.a.

245 a.a.

338 a.a.

56 a.a.

126 a.a.

PDB id:

9ivg

Name:

Membrane protein

Title:

Cryo-em structure of the glp-1(9-36)-bound human glp-1r-gs complex

Structure:

Glp-1(9-36). Chain: p. Engineered: yes. Glucagon-like peptide 1 receptor. Chain: r. Synonym: glp-1 receptor,glp-1-r,glp-1r. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: glp1r. Gene: gnai1, gnas, gnas1, gsp. Gene: gnb1. Gene: gng2.

Authors:

J.Li,G.Li,Y.Mai,X.Liu,D.Yang,Q.Zhou,M.-W.Wang

Key ref:

J.Li et al. Molecular basis of enhanced glp-1 signaling mediated glp-1(9–. Acta pharm sin b, . PubMed id: 39664415

Date:

23-Jul-24 Release date: 27-Nov-24

Protein chain

P01275  (GLUC_HUMAN) -  Pro-glucagon from Homo sapiens

Seq: 180 a.a.

Struc: 21 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 384 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 245 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 245 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

* PDB and UniProt seqs differ at 209 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????