PDBsum entry 9iqt

Membrane protein/immune system

PDB id: 9iqt

Contents

Protein chains

292 a.a.

227 a.a.

340 a.a.

61 a.a.

232 a.a.

Ligands

NIO

PDB id:

9iqt

Name:

Membrane protein/immune system

Title:

Structure of niacin-hca2-gi

Structure:

Hydroxycarboxylic acid receptor 2. Chain: r. Synonym: g-protein coupled receptor 109a,g-protein coupled receptor hm74a,niacin receptor 1,nicotinic acid receptor. Engineered: yes. Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hcar2, gpr109a, hca2, hm74a, niacr1. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: gnai1. Gene: gnb1. Gene: gng2.

Authors:

Y.Liu,Z.Zhou

Key ref:

Y.Liu et al. Ligand recognition and activation mechanism of the alicarboxylic acid receptors. To be published, . PubMed id: 39299383

Date:

13-Jul-24 Release date: 02-Oct-24

Protein chain

Q8TDS4  (HCAR2_HUMAN) -  Hydroxycarboxylic acid receptor 2 from Homo sapiens

Seq: 363 a.a.

Struc: 292 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 227 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 340 a.a.*

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 61 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????