PDBsum entry 9ijd

Membrane protein/immune system

PDB id: 9ijd

Contents

Protein chains

340 a.a.

128 a.a.

231 a.a.

252 a.a.

224 a.a.

52 a.a.

Ligands

CAU

PDB id:

9ijd

Name:

Membrane protein/immune system

Title:

Carazolol-activated human beta3 adrenergic receptor

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Camelid antibody vhh fragment. Chain: n. Engineered: yes. Single-chain fv16.

Source:

Rattus norvegicus. Norway rat. Organism_taxid: 10116. Gene: gnb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Lama glama. Organism_taxid: 9844. Expressed in: escherichia coli.

Authors:

S.Zheng,S.Zhang,S.Dai,K.Chen,K.Gao,B.Lin,X.Liu

Key ref:

S.Zheng et al. Molecular mechanism of the beta 3ar agonist activity beta-Blocker.. Chempluschem, . PubMed id: 39046191

Date:

22-Jun-24 Release date: 21-Aug-24

Protein chain

P54311  (GBB1_RAT) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Rattus norvegicus

Seq: 340 a.a.

Struc: 340 a.a.*

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

No UniProt id for this chain

Struc: 231 a.a.

Protein chain

P13945  (ADRB3_HUMAN) -  Beta-3 adrenergic receptor from Homo sapiens

Seq: 408 a.a.

Struc: 252 a.a.*

Protein chain

P04896  (GNAS2_BOVIN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Bos taurus

Seq: 394 a.a.

Struc: 224 a.a.*

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 52 a.a.

* PDB and UniProt seqs differ at 47 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????