PDBsum entry 9gl2

Membrane protein

PDB id: 9gl2

Contents

Protein chains

222 a.a.

331 a.a.

49 a.a.

291 a.a.

Ligands

CLR

T7M

ZKV

PDB id:

9gl2

Name:

Membrane protein

Title:

Befiradol-bound serotonin 5-ht1a receptor - gs protein complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Gene: htr1a, adrb2rl1, adrbrl1.

Authors:

J.Schneider,P.Gmeiner,B.Boettcher,T.Rasmussen

Key ref:

A.Ullrich et al. (2025). Discovery of a functionally selective serotonin recep (5-Ht 1a r) agonist for the treatment of pain.. Sci adv, 11, v9267. PubMed id: 40531992

Date:

26-Aug-24 Release date: 02-Jul-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 222 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 331 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 49 a.a.

Protein chain

P08908  (5HT1A_HUMAN) -  5-hydroxytryptamine receptor 1A from Homo sapiens

Seq: 422 a.a.

Struc: 291 a.a.*

* PDB and UniProt seqs differ at 9 residue positions (black crosses)