PDBsum entry 9eea

Signaling protein/immune system

PDB id: 9eea

Contents

Protein chains

265 a.a.

336 a.a.

52 a.a.

230 a.a.

128 a.a.

Ligands

ADN

PDB id:

9eea

Name:

Signaling protein/immune system

Title:

Cryo-em structure of the adenosine a2a receptor intermediate bound to a minigs heterotrimer

Structure:

Adenosine receptor a2a. Chain: a. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: adora2a, adora2. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Authors:

M.Bi,X.Wang,L.Ye,Y.Cheng

Key ref:

M.Bi et al. (2025). Structure and function of a near fully-Activated intermediate gpcr-G alpha beta gamma complex.. Nat commun, 16, 1100. PubMed id: 39875358

Date:

18-Nov-24 Release date: 09-Apr-25

Protein chain

P29274  (AA2AR_HUMAN) -  Adenosine receptor A2a from Homo sapiens

Seq: 412 a.a.

Struc: 265 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 336 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 52 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 230 a.a.*

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain D: E.C.3.6.5.- - ?????