PDBsum entry 9ebn

Membrane protein

PDB id: 9ebn

Contents

Protein chains

231 a.a.

337 a.a.

53 a.a.

125 a.a.

255 a.a.

PDB id:

9ebn

Name:

Membrane protein

Title:

Peptide 1 (glp-1 (aib16, acpc18)) bound to glp-1r/gs complex

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

B.P.Cary,M.V.Hager,Z.Mariam,R.K.Morris,M.J.Belousoff,G.Deganutti, D.Wootten,P.M.Sexton,S.H.Gellman

Key ref:

B.P.Cary et al. Prolonged signaling of backbone-Modified glucagon-Lik peptide-1 analogues with diverse receptor trafficking. To be published, . PubMed id: 40168114

Date:

12-Nov-24 Release date: 26-Mar-25

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 231 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 337 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 125 a.a.

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 255 a.a.*

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????