PDBsum entry 9eah

Membrane protein

PDB id: 9eah

Contents

Protein chains

378 a.a.

121 a.a.

107 a.a.

96 a.a.

Ligands

OLM

CLR

PDB id:

9eah

Name:

Membrane protein

Title:

Structure of nanobody at209 in complex with the olmesartan-bound angiotensin ii type i receptor (at1r)

Structure:

Nanobody at209,type-1 angiotensin ii receptor,soluble cytochrome b562. Chain: a, b. Synonym: at1ar,at1br,angiotensin ii type-1 receptor,at1 receptor, cytochrome b-562. Engineered: yes. Mutation: yes. Bag2 anti-bril fab heavy chain. Chain: c.

Source:

Camelidae, homo sapiens, escherichia coli. Human. Organism_taxid: 9835, 9606, 562. Gene: agtr1, agtr1a, agtr1b, at2r1, at2r1b, cybc. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293r. Synthetic construct. Organism_taxid: 32630.

Authors:

M.A.Skiba,A.C.Kruse

Key ref:

M.A.Skiba et al. (2025). Epitope-Directed selection of gpcr nanobody ligands w evolvable function. Proc natl acad sci usa, 122, . PubMed id: 40067891

Date:

11-Nov-24 Release date: 05-Mar-25

Protein chain

P30556  (AGTR1_HUMAN) -  Type-1 angiotensin II receptor from Homo sapiens

Seq: 359 a.a.

Struc: 378 a.a.*

Protein chain

No UniProt id for this chain

Struc: 121 a.a.

Protein chain

No UniProt id for this chain

Struc: 107 a.a.

Protein chain

P30556  (AGTR1_HUMAN) -  Type-1 angiotensin II receptor from Homo sapiens

Seq: 359 a.a.

Struc: 96 a.a.*

* PDB and UniProt seqs differ at 146 residue positions (black crosses)