PDBsum entry 9d0a

Immune system

PDB id: 9d0a

Contents

Protein chains

303 a.a.

32 a.a.

233 a.a.

301 a.a.

214 a.a.

PDB id:

9d0a

Name:

Immune system

Title:

Cryoem structure of par2 with endogenous tethered ligand.

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: g. Synonym: g gamma-i.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gng2. Unidentified. Organism_taxid: 32644.

Authors:

Z.Lyu,X.Lyu,A.P.Mcgrath,Y.Kang

Key ref:

Z.Lyu et al. (2025). Structural basis for the activation of proteinase-Act receptors par1 and par2.. Nat commun, 16, 3931. PubMed id: 40287415

Date:

06-Aug-24 Release date: 07-May-25

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 303 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 32 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Protein chain

P55085  (PAR2_HUMAN) -  Proteinase-activated receptor 2 from Homo sapiens

Seq: 397 a.a.

Struc: 301 a.a.*

Protein chain

P50148  (GNAQ_HUMAN) -  Guanine nucleotide-binding protein G(q) subunit alpha from Homo sapiens

Seq: 359 a.a.

Struc: 214 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 214 a.a.*

* PDB and UniProt seqs differ at 190 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????