PDBsum entry 9cib

Membrane protein

PDB id: 9cib

Contents

Protein chain

290 a.a.

Ligands

XI9

PDB id:

9cib

Name:

Membrane protein

Title:

Cryoem structure of hca2 dreadd gi1 in complex with fch-2296413 (local refinement)

Structure:

Hydroxycarboxylic acid receptor 2. Chain: r. Synonym: g-protein coupled receptor 109,g-protein coupled receptor 109a,g-protein coupled receptor hm74,niacin receptor 1,nicotinic acid receptor,protein puma-g. Engineered: yes. Mutation: yes. Other_details: protein starts at m1, gtt sequence from protease cleavage site, mutation d120a, mutation r108k to convert wt to

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: hcar2, gpr109, gpr109a, gpr109b, niacr1, pumag. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Authors:

B.E.Krumm,H.J.Kang,J.F.Diberto,N.J.Kapolka,R.H.Gumpper,R.H.J.Olsen, X.P.Huang,S.Zhang,J.F.Fay,B.L.Roth

Key ref:

H.J.Kang et al. (2024). Structure-Guided design of a peripherally restricted chemogenetic system.. Cell, 187, 7433. PubMed id: 39631393 DOI: 10.1016/J.CELL.2024.11.001

Date:

03-Jul-24 Release date: 14-May-25

Protein chain

Q9EP66  (HCAR2_MOUSE) -  Hydroxycarboxylic acid receptor 2 from Mus musculus

Seq: 360 a.a.

Struc: 290 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)