PDBsum entry 9c0k

Membrane protein

PDB id: 9c0k

Contents

Protein chains

374 a.a.

28 a.a.

200 a.a.

338 a.a.

57 a.a.

126 a.a.

Waters ×2

PDB id:

9c0k

Name:

Membrane protein

Title:

Cryo-em structure of glucagon-like peptide-1 receptor (glp-1r)-gs complex with exendin-phe1

Structure:

Glucagon-like peptide 1 receptor. Chain: r. Synonym: glp-1r. Engineered: yes. Exendin-4. Chain: p. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: glp1r. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Synthetic construct. Organism_taxid: 32630. Expressed in: synthetic construct.

Authors:

X.Zhang,R.Johnson,M.J.Belousoff,R.Danev,P.M.Sexton,D.Wootten

Key ref:

X.Zhang et al. Structural insights into the activation of glp-1r by ligands. To be published, .

Date:

25-May-24 Release date: 11-Jun-25

Protein chain

P43220  (GLP1R_HUMAN) -  Glucagon-like peptide 1 receptor from Homo sapiens

Seq: 463 a.a.

Struc: 374 a.a.*

Protein chain

C6EVG1  (EXE4_HELSC) -  Exendin-4 from Heloderma suspectum cinctum

Seq: 87 a.a.

Struc: 28 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 200 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

* PDB and UniProt seqs differ at 41 residue positions (black crosses)