PDBsum entry 9blc

Membrane protein

PDB id: 9blc

Contents

Protein chains

33 a.a.

370 a.a.

228 a.a.

339 a.a.

55 a.a.

128 a.a.

PDB id:

9blc

Name:

Membrane protein

Title:

Human calcitonin receptor in complex with gs and cagrilintide backbone (non-acylated) in ct-like conformation

Structure:

Cagrilintide backbone (non-acylated). Chain: p. Engineered: yes. Calcitonin receptor. Chain: r. Synonym: ct-r. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short.

Source:

Synthetic: yes. Homo sapiens. Human. Organism_taxid: 9606. Gene: calcr. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnas, gnas1, gsp. Gene: gnb1.

Authors:

J.Cao,M.J.Belousoff,D.L.Wootten,P.M.Sexton

Key ref:

J.Cao et al. Human calcitonin receptor in complex with gs and cagrilintide backbone (non-Acylated) in ct-Like confo. To be published, . PubMed id: 40204768

Date:

30-Apr-24 Release date: 16-Apr-25

Protein chain

P10997  (IAPP_HUMAN) -  Islet amyloid polypeptide from Homo sapiens

Seq: 89 a.a.

Struc: 33 a.a.*

Protein chain

P30988  (CALCR_HUMAN) -  Calcitonin receptor from Homo sapiens

Seq: 474 a.a.

Struc: 370 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 228 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 14 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????