PDBsum entry 9bkj

Membrane protein

PDB id: 9bkj

Contents

Protein chains

339 a.a.

57 a.a.

283 a.a.

204 a.a.

Ligands

ASP-TYS-MET-GLY-TRP-MET-ASP-PHE

NH2

PDB id:

9bkj

Name:

Membrane protein

Title:

Cholecystokinin 1 receptor (cck1r) y140a mutant, gq chimera (mgsqi) complex

Structure:

Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2. Chain: g. Synonym: g gamma-i.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gng2. Synthetic: yes. Gene: cckar, cckra.

Authors:

B.P.Cary,K.G.Harikumar,P.Zhao,A.J.Desai,J.M.Mobbs,C.Toufaily, S.G.B.Furness,A.Christopoulos,M.J.Belousoff,D.Wootten,P.M.Sexton, L.J.Miller

Key ref:

K.G.Harikumar et al. Cholesterol-Dependent dynamic changes in the conforma the type 1 cholecystokinin receptor affect ligand bin and g protein coupling. To be published, . PubMed id: 39083706

Date:

29-Apr-24 Release date: 22-May-24

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

Protein chain

P32238  (CCKAR_HUMAN) -  Cholecystokinin receptor type A from Homo sapiens

Seq: 428 a.a.

Struc: 283 a.a.*

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 204 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 204 a.a.*

* PDB and UniProt seqs differ at 186 residue positions (black crosses)