PDBsum entry 9b5y

Signaling protein

PDB id: 9b5y

Contents

Protein chains

249 a.a.

222 a.a.

26 a.a.

339 a.a.

232 a.a.

57 a.a.

PDB id:

9b5y

Name:

Signaling protein

Title:

Cryo-em structure of the lapth-bound pth1r in complex with gq

Structure:

Parathyroid hormone/parathyroid hormone-related peptide receptor. Chain: r. Engineered: yes. Guanine nucleotide-binding protein g(q). Chain: a. Engineered: yes. Long-acting parathyroid hormone analog. Chain: l.

Source:

Homo sapiens. Organism_taxid: 9606. Gene: pth1r. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnaq. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Human.

Authors:

X.Zhang,H.Liu,C.Zhang,J.-P.Vilardaga

Key ref:

X.Zhang et al. Cryo-Em structure of the lapth-Bound pth1r in complex gq. To be published, . PubMed id: 40138341

Date:

22-Mar-24 Release date: 19-Mar-25

Protein chain

Q03431  (PTH1R_HUMAN) -  Parathyroid hormone/parathyroid hormone-related peptide receptor from Homo sapiens

Seq: 593 a.a.

Struc: 249 a.a.

Protein chain

A0A8D2GGC9  (A0A8D2GGC9_THEGE) -  Guanine nucleotide-binding protein subunit alpha from Theropithecus gelada

Seq: 359 a.a.

Struc: 222 a.a.*

Protein chain

F5GZD9  (F5GZD9_HUMAN) -  Parathyroid hormone-related protein (Fragment) from Homo sapiens

Seq: 172 a.a.

Struc: 26 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 57 a.a.

* PDB and UniProt seqs differ at 59 residue positions (black crosses)