PDBsum entry 9auc

Membrane protein

PDB id: 9auc

Contents

Protein chains

231 a.a.

339 a.a.

55 a.a.

128 a.a.

117 a.a.

38 a.a.

368 a.a.

Ligands

PLM ×5

NAG ×3

Y01 ×2

Waters ×16

PDB id:

9auc

Name:

Membrane protein

Title:

Human amylin1 receptor in complex with gs and human calcitonin gene- related peptide

Structure:

Guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-stimulating g alpha protein. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1. Chain: b. Synonym: transducin beta chain 1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnas, gnas1, gsp. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gnb1. Gene: gng2. Lama glama.

Authors:

J.Cao,M.J.Belousoff,D.L.Wootten,P.M.Sexton

Key ref:

J.Cao et al. Cryo-Em structure of the human amylin 1 receptor in c with cgrp and gs protein.. Biochemistry, . PubMed id: 38603770

Date:

28-Feb-24 Release date: 24-Apr-24

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 231 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

Protein chain

O60894  (RAMP1_HUMAN) -  Receptor activity-modifying protein 1 from Homo sapiens

Seq: 148 a.a.

Struc: 117 a.a.

Protein chain

P06881  (CALCA_HUMAN) -  Calcitonin gene-related peptide 1 from Homo sapiens

Seq: 128 a.a.

Struc: 38 a.a.*

Protein chain

P30988  (CALCR_HUMAN) -  Calcitonin receptor from Homo sapiens

Seq: 474 a.a.

Struc: 368 a.a.

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????