PDBsum entry 9ary

Membrane protein

PDB id: 9ary

Contents

Protein chains

256 a.a.

232 a.a.

338 a.a.

53 a.a.

228 a.a.

Ligands

SRO

PDB id:

9ary

Name:

Membrane protein

Title:

Global reconstruction 5-ht2ar bound to 5-ht in complex with a mini-gq protein and scfv16 obtained by cryo-electron microscopy (cryoem)

Structure:

5-hydroxytryptamine receptor 2a. Chain: a. Synonym: 5-ht-2,5-ht-2a,serotonin receptor 2a. Engineered: yes. G subunit q (gi2-mini-gq chimeric). Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: htr2a, htr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2.

Authors:

R.H.Gumpper,J.F.Fay,B.L.Roth

Key ref:

R.H.Gumpper et al. (2025). The structural diversity of psychedelic drug actions revealed.. Nat commun, 16, 2734. PubMed id: 40108183

Date:

24-Feb-24 Release date: 02-Apr-25

Protein chain

P28223  (5HT2A_HUMAN) -  5-hydroxytryptamine receptor 2A from Homo sapiens

Seq: 471 a.a.

Struc: 256 a.a.

Protein chain

No UniProt id for this chain

Struc: 232 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 53 a.a.

Protein chain

No UniProt id for this chain

Struc: 228 a.a.