PDBsum entry 8yw5

Structural protein

PDB id: 8yw5

Contents

Protein chains

30 a.a.

379 a.a.

225 a.a.

339 a.a.

56 a.a.

128 a.a.

PDB id:

8yw5

Name:

Structural protein

Title:

Cryo-em structure of the retatrutide-bound human gcgr-gs complex

Structure:

Retatrutide. Chain: p. Engineered: yes. Glucagon receptor. Chain: r. Synonym: gl-r. Engineered: yes. Guanine nucleotide-binding protein g(s) subunit alpha isoforms short.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Human. Gene: gcgr. Gene: gnas, gnas1, gsp. Gene: gnb1. Gene: gng2.

Authors:

W.Z.Li,Q.T.Zhou,Z.T.Cong,Q.N.Yuan,W.X.Li,F.H.Zhao,H.E.Xu,L.H.Zhao, D.H.Yang,M.W.Wang

Key ref:

W.Li et al. (2024). Structural insights into the triple agonism at glp-1r and gcgr manifested by retatrutide.. Cell discov, 10, 77. PubMed id: 39019866

Date:

29-Mar-24 Release date: 07-Aug-24

Protein chain

No UniProt id for this chain

Struc: 30 a.a.

Protein chain

P47871  (GLR_HUMAN) -  Glucagon receptor from Homo sapiens

Seq: 477 a.a.

Struc: 379 a.a.

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 225 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 339 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 56 a.a.

Protein chain

No UniProt id for this chain

Struc: 128 a.a.

* PDB and UniProt seqs differ at 55 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????