PDBsum entry 8ybk

DNA binding protein/DNA

PDB id: 8ybk

Contents

Protein chains

78 a.a.

82 a.a.

99 a.a.

95 a.a.

DNA/RNA

PDB id:

8ybk

Name:

DNA binding protein/DNA

Title:

Cryo-em structure of the human nucleosome containing the h3.1 e97k mutant

Structure:

Histone h3.1. Chain: a, e. Synonym: histone h3/a,histone h3/b,histone h3/c,histone h3/d,histone h3/f,histone h3/h,histone h3/i,histone h3/j,histone h3/k,histone h3/l. Engineered: yes. Mutation: yes. Histone h4. Chain: b, f.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: h3c1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: h4c1. Gene: h2ac4. Gene: h2bc11.

Authors:

T.Kimura,S.Hirai,T.Kujirai,M.Ogasawara,Y.Takizawa,H.Kurumizaka

Key ref:

T.Kimura et al. Cryo-Em structure and biochemical analyses of the nuc containing the cancer-Associated histone h3 mutation. Genes cells, . PubMed id: 38972377

Date:

14-Feb-24 Release date: 24-Jul-24

Protein chains

P68431  (H31_HUMAN) -  Histone H3.1 from Homo sapiens

Seq: 136 a.a.

Struc: 78 a.a.*

Protein chains

P62805  (H4_HUMAN) -  Histone H4 from Homo sapiens

Seq: 103 a.a.

Struc: 82 a.a.

Protein chains

P04908  (H2A1B_HUMAN) -  Histone H2A type 1-B/E from Homo sapiens

Seq: 130 a.a.

Struc: 99 a.a.

Protein chains

P06899  (H2B1J_HUMAN) -  Histone H2B type 1-J from Homo sapiens

Seq: 126 a.a.

Struc: 95 a.a.

* PDB and UniProt seqs differ at 1 residue position (black cross)

DNA/RNA chains

G-T-G-C-C-G-A-G-G-C-C-G-C-T-C-A-A-T-T-G-G-T-C-G-T-A-G-A-C-A-G-C-T-C-T-A-G-C-A- 114 bases

A-C-G-T-G-C-C-T-G-G-A-G-A-C-T-A-G-G-G-A-G-T-A-A-T-C-C-C-C-T-T-G-G-C-G-G-T-T-A- 114 bases