|
|
||
|
|
|
|
|
UniProt functional annotation for P19876 | ||
|
|
|
|
|
|
||
| UniProt code: P19876. |
|
||
| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
|
||
|
||
| Function: | |
Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. {ECO:0000250, ECO:0000269|PubMed:10095777}. |
|
||
| Subcellular location: | |
Secreted. |
| Ptm: | |
N-terminal processed form GRO-gamma(5-73) is produced by proteolytic cleavage after secretion from peripheral blood monocytes. {ECO:0000269|PubMed:10095777}. |
| Similarity: | |
Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.