UniProt functional annotation for P10145



	UniProt functional annotation for P10145

UniProt code: P10145.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. {ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672}.

Subunit: Homodimer (PubMed:31235521). Dimer formation is disrupted by tick evasin-3 (PubMed:31235521). {ECO:0000269|PubMed:31235521}.

Subcellular location: Secreted.

Induction: By ER stress in a DDIT3/CHOP-dependent manner. {ECO:0000269|PubMed:20829347}.

Ptm: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. {ECO:0000269|PubMed:11023497, ECO:0000269|PubMed:11978786, ECO:0000269|PubMed:2145175, ECO:0000269|PubMed:2212672, ECO:0000269|PubMed:2523801, ECO:0000269|PubMed:2648135}.

Ptm: Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. {ECO:0000269|PubMed:18710930, ECO:0000269|PubMed:19608678}.

Similarity: Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.

Sequence caution: Sequence=AAK00048.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. {ECO:0000269\|PubMed:11978786, ECO:0000269\|PubMed:2145175, ECO:0000269\|PubMed:2212672}.


Subunit:		Homodimer (PubMed:31235521). Dimer formation is disrupted by tick evasin-3 (PubMed:31235521). {ECO:0000269\|PubMed:31235521}.
Subcellular location:		Secreted.
Induction:		By ER stress in a DDIT3/CHOP-dependent manner. {ECO:0000269\|PubMed:20829347}.
Ptm:		Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. {ECO:0000269\|PubMed:11023497, ECO:0000269\|PubMed:11978786, ECO:0000269\|PubMed:2145175, ECO:0000269\|PubMed:2212672, ECO:0000269\|PubMed:2523801, ECO:0000269\|PubMed:2648135}.
Ptm:		Citrullination at Arg-27 prevents proteolysis, and dampens tissue inflammation, it also enhances leukocytosis, possibly through impaired chemokine clearance from the blood circulation. {ECO:0000269\|PubMed:18710930, ECO:0000269\|PubMed:19608678}.
Similarity:		Belongs to the intercrine alpha (chemokine CxC) family. {ECO:0000305}.
Sequence caution:		Sequence=AAK00048.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305};