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UniProt functional annotation for P46091 | ||
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| UniProt code: P46091. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for the inflammation-associated leukocyte chemoattractant chemerin/RARRES2 suggesting a role for this receptor in the regulation of inflammation (PubMed:18165312). Receptor for TAFA1, mediates its effects on neuronal stem-cell proliferation and differentiation via the activation of ROCK/ERK and ROCK/STAT3 signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q8K087, ECO:0000269|PubMed:18165312}. |
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| Function: | |
(Microbial infection) Coreceptor for HIV-1. {ECO:0000269|PubMed:10233994}. |
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| Subcellular location: | |
Cell membrane {ECO:0000250|UniProtKB:Q8K087}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes in presence of its ligand, TAFA1. {ECO:0000250|UniProtKB:Q8K087}. |
| Tissue specificity: | |
Expressed in hippocampus. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
Annotations taken from UniProtKB at the EBI.