PDBsum entry 8x5x

Membrane protein

PDB id: 8x5x

Contents

Protein chain

256 a.a.

PDB id:

8x5x

Name:

Membrane protein

Title:

Cryoem structure of the histamine h1 receptor in apo-form

Structure:

Histamine h1 receptor,soluble cytochrome b562. Chain: b. Synonym: h1r,hh1r,cytochrome b-562. Engineered: yes. Mutation: yes

Source:

Homo sapiens, escherichia coli. Human. Organism_taxid: 9606, 562. Gene: hrh1. Expressed in: spodoptera aff. Frugiperda 1 bold-2017. Expression_system_taxid: 2449148.

Authors:

D.D.Wang,Q.Guo,Y.Y.Tao

Key ref:

D.Wang et al. (2024). Molecular mechanism of antihistamines recognition and regulation of the histamine h 1 receptor.. Nat commun, 15, 84. PubMed id: 38167898

Date:

20-Nov-23 Release date: 17-Jan-24

Protein chain

P0ABE7  (C562_ECOLX) -  Soluble cytochrome b562 from Escherichia coli

Seq: 128 a.a.

Struc: 256 a.a.*

Protein chain

P35367  (HRH1_HUMAN) -  Histamine H1 receptor from Homo sapiens

Seq: 487 a.a.

Struc: 256 a.a.*

* PDB and UniProt seqs differ at 106 residue positions (black crosses)