PDBsum entry 8x0e

Membrane protein

PDB id: 8x0e

Contents

Protein chains

765 a.a.

Ligands

NAG ×2

QUS ×2

PDB id:

8x0e

Name:

Membrane protein

Title:

Human fl metabotropic glutamate receptor 5, mglu5-5m with agonist and pam, w785a mutant

Structure:

Metabotropic glutamate receptor 5. Chain: a, b. Engineered: yes. Mutation: yes. Other_details: the n-terminal sequence (dykddddkhhhhhhhhhhlevlfqgp) is the tag and linker), which has been cleaved by protease before structural experiment. Here, it is included for completion. The sequence when compared to uniprot starts at 21 and ends at 856 (construct used for expression). The construct has the following

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: grm5. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnt-

Authors:

K.R.Vinothkumar,G.Lebon,G.Cannone

Key ref:

K.R.Vinothkumar et al. Conformational diversity in class c gpcr positive all modulation. To be published, . PubMed id: 39805839

Date:

04-Nov-23 Release date: 06-Nov-24

Protein chains

P41594  (GRM5_HUMAN) -  Metabotropic glutamate receptor 5 from Homo sapiens

Seq: 1212 a.a.

Struc: 765 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)