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UniProt functional annotation for Q99705 | ||
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| UniProt code: Q99705. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis. {ECO:0000269|PubMed:10421367}. |
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| Subunit: | |
Interacts with NCDN. {ECO:0000269|PubMed:16945926}. |
| Subcellular location: | |
Cell membrane; Multi-pass membrane protein. |
| Tissue specificity: | |
Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart. |
| Similarity: | |
Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}. |
| Sequence caution: | |
Sequence=AAC14587.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.