PDBsum entry 8v6u

Membrane protein

PDB id: 8v6u

Contents

Protein chains

260 a.a.

211 a.a.

338 a.a.

51 a.a.

230 a.a.

Ligands

YEQ

PDB id:

8v6u

Name:

Membrane protein

Title:

5ht2ar-minigq heterotrimer in complex with a novel agonist obtained from large scale docking

Structure:

5-hydroxytryptamine receptor 2a. Chain: a. Synonym: 5-ht-2,5-ht-2a,serotonin receptor 2a. Engineered: yes. G protein alpha-subunit q (gi2-mini-gq chimera). Chain: b. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: htr2a, htr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gng2. Expression_system_taxid: 7108

Authors:

R.H.Gumpper,L.Wang,N.Kapolka,G.Skiniotis,B.L.Roth

Key ref:

J.Lyu et al. Alphafold2 structures guide prospective ligand discov. Science, . PubMed id: 38753765

Date:

03-Dec-23 Release date: 29-May-24

Protein chain

P28223  (5HT2A_HUMAN) -  5-hydroxytryptamine receptor 2A from Homo sapiens

Seq: 471 a.a.

Struc: 260 a.a.

Protein chain

No UniProt id for this chain

Struc: 211 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 51 a.a.

Protein chain

No UniProt id for this chain

Struc: 230 a.a.