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UniProt functional annotation for Q93UJ2 | ||
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| UniProt code: Q93UJ2. |
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| Organism: | |
Burkholderia pseudomallei (strain K96243). |
| Taxonomy: | |
Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; Burkholderiaceae; Burkholderia; pseudomallei group. |
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| Function: | |
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. {ECO:0000269|PubMed:20447408}. |
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| Catalytic activity: | |
Reaction=2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno- heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate; Xref=Rhea:RHEA:27489, ChEBI:CHEBI:57483, ChEBI:CHEBI:60203, ChEBI:CHEBI:60204; EC=5.3.1.28; Evidence={ECO:0000269|PubMed:20447408}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:20447408}; Note=Binds 1 zinc ion per subunit. {ECO:0000269|PubMed:20447408}; |
| Pathway: | |
Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7- phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7- phosphate: step 1/1. |
| Pathway: | |
Capsule biogenesis; capsule polysaccharide biosynthesis. |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:20447408}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. |
| Miscellaneous: | |
The reaction produces a racemic mixture of D-glycero- alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7- phosphate. |
| Similarity: | |
Belongs to the SIS family. GmhA subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.