UniProt functional annotation for P49956



	UniProt functional annotation for P49956

UniProt code: P49956.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. {ECO:0000269|PubMed:11287619, ECO:0000269|PubMed:11389843, ECO:0000269|PubMed:11486023, ECO:0000269|PubMed:15964801}.

Subunit: Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. CTF18 interacts with ECO1. {ECO:0000269|PubMed:11287619, ECO:0000269|PubMed:11389843, ECO:0000269|PubMed:11486023, ECO:0000269|PubMed:12665596, ECO:0000269|PubMed:15964801}.

Subcellular location: Nucleus {ECO:0000305}.

Similarity: Belongs to the activator 1 small subunits family. CTF18 subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Essential for the fidelity of chromosome transmission. Required for the DNA replication block checkpoint. Component of the RFC-like complex CTF18-RFC which is required for efficient establishment of chromosome cohesion during S-phase and may load or unload POL30/PCNA. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. {ECO:0000269\|PubMed:11287619, ECO:0000269\|PubMed:11389843, ECO:0000269\|PubMed:11486023, ECO:0000269\|PubMed:15964801}.


Subunit:		Component of the CTF18-RFC complex, which consists of CTF18, CTF8, DCC1, RFC2, RFC3, RFC4 and RFC5. CTF18 interacts with ECO1. {ECO:0000269\|PubMed:11287619, ECO:0000269\|PubMed:11389843, ECO:0000269\|PubMed:11486023, ECO:0000269\|PubMed:12665596, ECO:0000269\|PubMed:15964801}.
Subcellular location:		Nucleus {ECO:0000305}.
Similarity:		Belongs to the activator 1 small subunits family. CTF18 subfamily. {ECO:0000305}.