UniProt functional annotation for P31422

UniProt code: P31422.

Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.
Function:		G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Subunit:		Interacts with TAMALIN. {ECO:0000269|PubMed:11850456}.
Subcellular location:		Cell membrane; Multi-pass membrane protein.
Tissue specificity:		Is widely distributed in the CNS. Predominant expression is seen in the neuronal cells of the cerebral cortex, dentate gyrus, and glial cells throughout brain regions.
Similarity:		Belongs to the G-protein coupled receptor 3 family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.