UniProt functional annotation for P40227



	UniProt functional annotation for P40227

UniProt code: P40227.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269|PubMed:25467444, ECO:0000305}.

Subunit: Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:25467444). Interacts with PACRG (PubMed:14532270). {ECO:0000269|PubMed:14532270, ECO:0000269|PubMed:25467444}.

Subcellular location: Cytoplasm {ECO:0000269|PubMed:8034610}.

Similarity: Belongs to the TCP-1 chaperonin family. {ECO:0000305}.

Sequence caution: Sequence=AAA58676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BU540578; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). The TRiC complex plays a role in the folding of actin and tubulin (Probable). {ECO:0000269\|PubMed:25467444, ECO:0000305}.


Subunit:		Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter (PubMed:25467444). Interacts with PACRG (PubMed:14532270). {ECO:0000269\|PubMed:14532270, ECO:0000269\|PubMed:25467444}.
Subcellular location:		Cytoplasm {ECO:0000269\|PubMed:8034610}.
Similarity:		Belongs to the TCP-1 chaperonin family. {ECO:0000305}.
Sequence caution:		Sequence=AAA58676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BU540578; Type=Miscellaneous discrepancy; Note=Several sequencing errors.; Evidence={ECO:0000305};