PDBsum entry 8k3z

Immune system

PDB id: 8k3z

Contents

Protein chains

296 a.a.

338 a.a.

233 a.a.

62 a.a.

55 a.a.

233 a.a.

PDB id:

8k3z

Name:

Immune system

Title:

Cryo-em structure of cxcr4 in complex with cxcl12

Structure:

C-x-c chemokine receptor type 4. Chain: a. Synonym: cxc-r4,cxcr-4,fb22,fusin,hm89,lcr1,leukocyte-derived seven transmembrane domain receptor,lestr,lipopolysaccharide-associated protein 3,lap-3,lps-associated protein 3,npyrl,stromal cell-derived factor 1 receptor,sdf-1 receptor. Engineered: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cxcr4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Gene: gnai1. Gene: cxcl12, sdf1, sdf1a, sdf1b.

Authors:

Y.Z.Liu,A.J.Liu,Q.W.Liao,R.D.Ye

Key ref:

Y.Z.Liu et al. Cryo-Em structure of cxcr4 in complex with cxcl12. To be published, . PubMed id: 39093700

Date:

17-Jul-23 Release date: 17-Jul-24

Protein chain

P61073  (CXCR4_HUMAN) -  C-X-C chemokine receptor type 4 from Homo sapiens

Seq: 352 a.a.

Struc: 296 a.a.

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 338 a.a.

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 233 a.a.

Protein chain

P48061  (SDF1_HUMAN) -  Stromal cell-derived factor 1 from Homo sapiens

Seq: 93 a.a.

Struc: 62 a.a.

Protein chain

P59768  (GBG2_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Homo sapiens

Seq: 71 a.a.

Struc: 55 a.a.

Protein chain

No UniProt id for this chain

Struc: 233 a.a.

Enzyme reactions

• Enzyme class: Chain C: E.C.3.6.5.- - ?????