UniProt functional annotation for Q14832



	UniProt functional annotation for Q14832

UniProt code: Q14832.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.

Subunit: Interacts with TAMALIN. {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:8840013}; Multi-pass membrane protein {ECO:0000269|PubMed:8840013}.

Tissue specificity: Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. {ECO:0000269|PubMed:8840013}.

Miscellaneous: [Isoform 2]: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain. {ECO:0000305}.

Similarity: Belongs to the G-protein coupled receptor 3 family. {ECO:0000305}.

Sequence caution: Sequence=AAD15616.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269\|PubMed:8840013}.


Subunit:		Interacts with TAMALIN. {ECO:0000250}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:8840013}; Multi-pass membrane protein {ECO:0000269\|PubMed:8840013}.
Tissue specificity:		Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala. {ECO:0000269\|PubMed:8840013}.
Miscellaneous:		[Isoform 2]: Appears to be membrane-associated, despite the absence of the seven-transmembrane domain. {ECO:0000305}.
Similarity:		Belongs to the G-protein coupled receptor 3 family. {ECO:0000305}.
Sequence caution:		Sequence=AAD15616.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=ABC47402.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=CAA54796.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};