PDBsum entry 8ity

Transcription

PDB id: 8ity

Contents

Protein chains

146 a.a.

374 a.a.

365 a.a.

1378 a.a.

1105 a.a.

343 a.a.

122 a.a.

209 a.a.

76 a.a.

166 a.a.

148 a.a.

56 a.a.

65 a.a.

103 a.a.

46 a.a.

394 a.a.

146 a.a.

512 a.a.

232 a.a.

87 a.a.

176 a.a.

361 a.a.

111 a.a.

DNA/RNA

Ligands

SF4

Metals

_MG

_ZN ×7

PDB id:

8ity

Name:

Transcription

Title:

Human RNA polymerase iii pre-initiation complex closed DNA 1

Structure:

Snrna-activating protein complex subunit 1. Chain: 1. Synonym: snapc subunit 1,proximal sequence element-binding transcription factor subunit gamma,pse-binding factor subunit gamma, ptf subunit gamma,small nuclear RNA-activating complex polypeptide 1, snrna-activating protein complex 43 kda subunit,snapc 43 kda subunit. Engineered: yes. Snrna-activating protein complex subunit 3. Chain: 3.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: snapc1, snap43. Expressed in: homo sapiens. Expression_system_taxid: 9606. Gene: snapc3, snap50. Gene: snapc4, snap190. Gene: polr3a.

Authors:

H.Hou,Q.Jin,Y.Ren,Q.Wang,Y.Xu

Key ref:

H.Hou et al. Structure of the snapc-Bound RNA polymerase III preinitiation complex.. Cell res, . PubMed id: 37165065

Date:

23-Mar-23 Release date: 07-Jun-23

Protein chain

Q16533  (SNPC1_HUMAN) -  snRNA-activating protein complex subunit 1 from Homo sapiens

Seq: 368 a.a.

Struc: 146 a.a.

Protein chain

Q92966  (SNPC3_HUMAN) -  snRNA-activating protein complex subunit 3 from Homo sapiens

Seq: 411 a.a.

Struc: 374 a.a.

Protein chain

Q5SXM2  (SNPC4_HUMAN) -  snRNA-activating protein complex subunit 4 from Homo sapiens

Seq: 1469 a.a.

Struc: 365 a.a.

Protein chain

O14802  (RPC1_HUMAN) -  DNA-directed RNA polymerase III subunit RPC1 from Homo sapiens

Seq: 1390 a.a.

Struc: 1378 a.a.

Protein chain

Q9NW08  (RPC2_HUMAN) -  DNA-directed RNA polymerase III subunit RPC2 from Homo sapiens

Seq: 1133 a.a.

Struc: 1105 a.a.

Protein chain

O15160  (RPAC1_HUMAN) -  DNA-directed RNA polymerases I and III subunit RPAC1 from Homo sapiens

Seq: 346 a.a.

Struc: 343 a.a.

Protein chain

O75575  (RPC9_HUMAN) -  DNA-directed RNA polymerase III subunit RPC9 from Homo sapiens

Seq: 148 a.a.

Struc: 122 a.a.

Protein chain

P19388  (RPAB1_HUMAN) -  DNA-directed RNA polymerases I, II, and III subunit RPABC1 from Homo sapiens

Seq: 210 a.a.

Struc: 209 a.a.

Protein chain

P61218  (RPAB2_HUMAN) -  DNA-directed RNA polymerases I, II, and III subunit RPABC2 from Homo sapiens

Seq: 127 a.a.

Struc: 76 a.a.

Protein chain

Q9Y535  (RPC8_HUMAN) -  DNA-directed RNA polymerase III subunit RPC8 from Homo sapiens

Seq: 204 a.a.

Struc: 166 a.a.

Protein chain

P52434  (RPAB3_HUMAN) -  DNA-directed RNA polymerases I, II, and III subunit RPABC3 from Homo sapiens

Seq: 150 a.a.

Struc: 148 a.a.

Protein chain

Q9Y2Y1  (RPC10_HUMAN) -  DNA-directed RNA polymerase III subunit RPC10 from Homo sapiens

Seq: 108 a.a.

Struc: 56 a.a.

Protein chain

P62875  (RPAB5_HUMAN) -  DNA-directed RNA polymerases I, II, and III subunit RPABC5 from Homo sapiens

Seq: 67 a.a.

Struc: 65 a.a.

Protein chain

P0DPB6  (RPAC2_HUMAN) -  DNA-directed RNA polymerases I and III subunit RPAC2 from Homo sapiens

Seq: 133 a.a.

Struc: 103 a.a.

Protein chain

P53803  (RPAB4_HUMAN) -  DNA-directed RNA polymerases I, II, and III subunit RPABC4 from Homo sapiens

Seq: 58 a.a.

Struc: 46 a.a.

Protein chain

Q9NVU0  (RPC5_HUMAN) -  DNA-directed RNA polymerase III subunit RPC5 from Homo sapiens

Seq: 708 a.a.

Struc: 394 a.a.

Protein chain

P05423  (RPC4_HUMAN) -  DNA-directed RNA polymerase III subunit RPC4 from Homo sapiens

Seq: 398 a.a.

Struc: 146 a.a.*

Protein chain

Q9BUI4  (RPC3_HUMAN) -  DNA-directed RNA polymerase III subunit RPC3 from Homo sapiens

Seq: 534 a.a.

Struc: 512 a.a.

Protein chain

Q9H1D9  (RPC6_HUMAN) -  DNA-directed RNA polymerase III subunit RPC6 from Homo sapiens

Seq: 316 a.a.

Struc: 232 a.a.

Protein chain

O15318  (RPC7_HUMAN) -  DNA-directed RNA polymerase III subunit RPC7 from Homo sapiens

Seq: 223 a.a.

Struc: 87 a.a.

Protein chain

P20226  (TBP_HUMAN) -  TATA-box-binding protein from Homo sapiens

Seq: 339 a.a.

Struc: 176 a.a.

Protein chain

Q9HAW0  (BRF2_HUMAN) -  Transcription factor IIIB 50 kDa subunit from Homo sapiens

Seq: 419 a.a.

Struc: 361 a.a.

Protein chain

A6H8Y1  (BDP1_HUMAN) -  Transcription factor TFIIIB component B'' homolog from Homo sapiens

Seq: 2624 a.a.

Struc: 111 a.a.

* PDB and UniProt seqs differ at 14 residue positions (black crosses)

DNA/RNA chains

A-T-A-T-G-C-T-T-A-C-C-G-T-A-A-C-T-T-G-A-A-A-G-T-A-T-T-T-C-G-A-T-T-T-C-T-T-G-G- 82 bases

G-A-A-G-C-G-A-G-C-A-C-G-G-T-G-T-T-T-C-G-T-C-C-T-T-T-C-C-A-C-A-A-G-A-T-A-T-A-T- 82 bases

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.7.7.6 - DNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site