PDBsum entry 8iod

Membrane protein

PDB id: 8iod

Contents

Protein chains

234 a.a.

334 a.a.

52 a.a.

126 a.a.

270 a.a.

Ligands

ACE-NLE-ASP-PRO-4J2-ARG-TRP-LYS-NH2

Metals

_CA

PDB id:

8iod

Name:

Membrane protein

Title:

Cryo-em structure of the pg-901-bound human melanocortin receptor 5 (mc5r)-gs complex

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(s) subunit alpha isoforms short. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein,adenylate cyclase-stimulating g alpha protein. Engineered: yes. Mutation: yes. Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1,hibit.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gnai1, gnas, gnas1, gsp. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: gnb1. Bos taurus. Cattle.

Authors:

W.B.Feng,Q.T.Zhou,X.Y.Chen,A.T.Dai,X.Q.Cai,X.Liu,F.H.Zhao,Y.Chen, C.Y.Ye,Y.N.Xu,Z.T.Cong,H.Li,S.Lin,D.H.Yang,M.W.Wang

Key ref:

W.Feng et al. (2023). Structural insights into ligand recognition and subty selectivity of the human melanocortin-3 and melanocor receptors.. Cell discov, 9, 81. PubMed id: 37524700

Date:

10-Mar-23 Release date: 20-Sep-23

Protein chain

P63092  (GNAS2_HUMAN) -  Guanine nucleotide-binding protein G(s) subunit alpha isoforms short from Homo sapiens

Seq: 394 a.a.

Struc: 234 a.a.*

Protein chain

P63096  (GNAI1_HUMAN) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Homo sapiens

Seq: 354 a.a.

Struc: 234 a.a.*

Protein chain

P62873  (GBB1_HUMAN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 from Homo sapiens

Seq: 340 a.a.

Struc: 334 a.a.

Protein chain

P63212  (GBG2_BOVIN) -  Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 from Bos taurus

Seq: 71 a.a.

Struc: 52 a.a.

Protein chain

No UniProt id for this chain

Struc: 126 a.a.

Protein chain

P03435  (HEMA_I75A3) -  Hemagglutinin from Influenza A virus (strain A/Victoria/3/1975 H3N2)

Seq: 567 a.a.

Struc: 270 a.a.*

Protein chain

P33032  (MC5R_HUMAN) -  Melanocortin receptor 5 from Homo sapiens

Seq: 325 a.a.

Struc: 270 a.a.

* PDB and UniProt seqs differ at 361 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chain A: E.C.3.6.5.- - ?????